Since the introduction of the Registered General Nursing (Diploma) in 1999, the College has been working conscientiously with the Ministry of Health and the Nursing and Midwifery Council of Ghana to get the College accredited by the National Accreditation Board as a Diploma awarding institution. 

As a result, the National Accreditation Board visited the College in 2004 to assess the necessary facilities.

In 2005, the Accreditation Committee granted the College a three-year authorization with effect from 1st September, 2005 to continue with preparations for full accreditation. 

In 2007, the Ministry of Health signed the Memorandum of Understanding with the College of Health Sciences: University of Ghana, to get all the Nursing Training Colleges including the Holy Family Nursing and Midwifery Training College, Berekum affiliated to the School of Nursing to facilitate the award of academic diplomas to graduates. However, this memorandum was not successful. 

The College is now affiliated to the Kwame Nkrumah University of Science and Technology - Kumasi for the above purpose. The College is also affiliated to the University of Cape Coast for the Post Basic Midwifery Programme.

The National Accreditation Board, at its 63rd meeting held on October 4th 2007 approved and granted a five-year accreditation for the running of the College’s two programmes with effect from September 2007. This was renewed on the 1st of September, 2012 for another five year period.